Publication Details
Abstract
This study investigates the relationship between honeybee stings and human immune response, focusing on the elevation of total IgE levels as an indicator of immunological reaction. A total of 50 individuals, comprising both honeybee sting-exposed and control groups, were enrolled in the study. Within the honeybee sting-exposed group, 86% of participants exhibited elevated total IgE levels within 24 hours post-sting, ranging from 450 UI/ml to 690 UI/ml. In contrast, 14% of participants did not display increased IgE levels following Apis mellifera sting exposure. Notably, all control group participants maintained normal IgE levels. Statistical analysis using a chi-square test confirmed a significant association between honeybee sting exposure and elevated total IgE levels (χ² = 37.77, p < 0.05). These findings underscore the immunomodulatory effects of honeybee venom, implicating it in the induction of IgE-mediated immune responses in the majority of individuals. The observed variability in immune response highlights the complexity of host-venom interactions and warrants further investigation into underlying mechanisms. Understanding these immunological responses may inform strategies for bee sting allergy management and facilitate the development of therapeutic interventions leveraging honeybee venom immunomodulation.