Publication Details
Abstract
A prevalent endocrine condition that affects women of reproductive age is polycystic ovarian syndrome, or PCOS. New research suggests the protein asprosin, released during a state of fasting, could be important to the disease's mechanisms. Additionally, galanin-like peptides (GALP) are associated Considering human insulin sensitivity and body mass index (BMI). These peptides boost insulin signaling by influencing insulin receptors in adipose tissue, skeletal muscles, and the liver. The objective of the study was to measure the levels of Asprosin and galanin-like peptide in serum samples from women who have been diagnosed with polycystic ovarian syndrome (PCOS) and those who have not. The purpose was to explore their possible involvement in metabolic and hormonal changes of PCOS. The study was a cross sectional study and was performed at the Salahadeen General Hospital's Gynecology and Obstetrics Department for six months, from December 1, 2025, to June 30, 2026. One hundred women between the ages of 15 and 45 who had been diagnosed with PCOS were chosen as a suitable sample. According to this study, the two groups' metabolic indicators differed significantly. Specifically, compared to women in the control group, women with PCOS exhibited significantly lower (p<0.001) serum galanin-like peptide concentrations. The results showed the mean ± SD of the PCOS group's serum levels of galanin-like peptide. Additionally, compared to the controls, women with PCOS had considerably higher levels of asprosin (p<0.001). These results suggest a potential link between these biomarkers and the hormonal and metabolic abnormalities seen in PCOS.