Publication Details
Abstract
Multidrug-resistant (MDR) urinary tract infections (UTI) present a major therapeutic problem. Oxidative stress and inflammation could be involved in host response. Objectives to compare the oxidative and inflammatory markers in patients with MDR UTI and without MDR UTI compared to healthy controls. This is a cross-sectional comparative study. 90 adult patients were recruited into 3 groups (MDR UTI, non-MDR UTI, and healthy control), 30 patients per group. From the 60 patients with infection, one urine isolate was collected. Malondialdehyde (MDA) levels were measured using TBARS spectrophotometric method, total antioxidant capacity (TAC) using colorimetric kit and C reactive protein (CRP) and interleukin-6 (IL-6) using routine hospital methods. All were measured in serum. Results of 60 isolates, 50% were MDR. Most common isolate was Escherichia coli (55%). Patients with MDR had higher MDA (4.6±1.1nmol/ml), CRP (52.8±22.6mg/l) and IL-6 (38.4±15.2pg/ml), and lower TAC levels (0.88±0.21mmol/l) compared to patients with non-MDR and controls (p < 0.001). MDA was positively correlated with IL-6 (r = 0.58) and CRP levels (r = 0.49). TAC was negatively correlated with IL-6 (r=-0.52) and MDA (r=-0.61) levels (p < 0.001). MDR group had the highest percentage of patients with diabetes (33%). No adjustment was performed. MDR UTI were associated with increased oxidative stress, decreased antioxidant capacity and increased systemic inflammation.