Central Asian Journal of Medical and Natural Science

The results of alkaline activation of natural bentonite from the Logonsky deposit using a 2 wt.% sodium carbonate solution with variation of treatment temperature and duration are presented. The effect of activation conditions on the cation exchange capacity, as well as on the technological prope...

The Lead (Pb) exposure is a significant environmental health issue, exerting extensive adverse effects on several physiological systems. This study examined the preventive effects of nano-genistein, a soy-derived isoflavone, against lead-induced poisoning in male rats. The control group (C) had a...

This article presents the design, simulation, and analysis of a surface plasmon resonance (SPR) sensor based on solid twin-core photonic crystal fibers (PCFs) for detecting nitrate concentration in aqueous solutions. The motivation stems from the urgent need for sensitive, compact, real-time moni...

This research addressed the preparation and study of a ceramic-metal composite consisting of 65% MgO + 35% Ni using powder metallurgy technology, focusing on studying the effect of sintering temperature within the range (700–1100°C) on the microstructure and mechanical and physical properties of ...

Background: Glycemic control is still the most important aspect of T2DM treatment   sodium-glucose cotransporter-2 (SGLT2) inhibitor, empagliflozin, and metformin therapy has been shown to be effective and well tolerated in patients with T2DM and is first of the several recommended trea...

Background: Breast cancer is a complex malignancy characterized by uncontrolled proliferation of abnormal cells within breast tissue, and representing one of the most prevalent cancers affecting women globally leading to cancer-related mortality. Aim: Gene expression profiling of MTHFR-C677T to e...

Antimicrobial resistance (AMR) has become a growing global health concern due to the overuse and misuse of antibiotics in human medicine, agriculture, and animal care. This review aims to examine the major resistance genes, underlying mechanisms, and the potential of new-generation antibiotics in...

Urolithiasis (kidney and urinary tract stone disease) in premature children is a serious pediatric problem, and its early detection and prediction are of great importance in clinical practice. This article analyzes methods for determining the risk of developing urolithiasis based on urine metabol...

Perinatal central nervous system injury is a significant source of morbidity in the newborn population, especially among vulnerable groups such as small for gestational age newborns. Chronic intrauterine hypoxia related to growth restriction may make neurons vulnerable to injury during the birth ...

Respiratory tract infections are one of the major causes of morbidity and antibiotic consumption among children worldwide. Although many respiratory infections in children are viral in nature, antibiotics are commonly prescribed in practice, resulting in the development of antimicrobial resistanc...

Intrauterine growth restriction is also an important neonatal condition that relates to impaired metabolic adaptation after birth. Among the early problems encountered by the growth-restricted infants, there are disturbances in the metabolism of bilirubin that are quite relevant because of the ri...

The long-term effects of coronavirus disease 2019 (COVID-19) on paediatric health is an issue of growing concern, especially the possible occurrence of functional alterations of the respiratory system. Although children tend to have mild forms of acute cases of COVID-19, observations from clinica...

The post-transplant period is a defining moment in the evolution of contemporary transplantology and is largely responsible for long-term clinical outcomes and patient survival. While great progress in surgical techniques and perioperative management has been made and has led to better early post...

Background: Obesity is a major health issue in the world, with many chronic illnesses, such as cardiovascular disease and type 2 diabetes, being attributed to it. It is principally accompanied by systemic inflammation, which worsens these conditions. The effects of bariatric surgery on the inflam...

Incidental papillary thyroid carcinoma (IPTC) is commonly to be detected during thyroidectomy in the case of benign thyroid lesions. Two of the common underlying pathologies are the disease known as Graves' disease (GD) and euthyroid nodular goiter (ENG). This purpose study aimed to determine the...

Because diabetes upsets the oxidative equilibrium, it increases the risk of hepatic tissue problems.  There aren't many efficient therapies available for this common ailment right now.  Because ginseng extract and ginsenosides are known to have anti-inflammatory, anti-apoptotic, and antioxidant q...

This article describes the toxic waste emitted from the Tajik Aluminum Plant, relevant literature data, and their comprehensive analysis. The effects of fluoride compounds on the organism of calves were studied, and the toxic dynamics and toxic kinetics of fluoride compounds in the calf organism ...

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by synovial inflammation and progressive joint destruction. In patients with concomitant malignancies, chemotherapy represents a unique immunomodulatory intervention that may significantly influence RA disease ac...

The Optical multilayer perovskite thin films were integrated as a basic structure with smart window systems for Green buildings to to develop energy outputs, and the structure was numerically simulated due to its strong light–matter interaction and tunable optical and physical properties. We prop...

This study investigated the magnesium and iron content in the daily diets of pregnant women aged 21–34 years living in the Qashqadaryo region, as well as the concentrations of these minerals in their blood. According to the obtained results, the dietary magnesium intake of the participants was cl...

Pediatric asthma is a common chronic respiratory disease that severely affects the quality of life and daily functioning of children affected by the disease.   Allergen-specific immunotherapy (AIT) has developed as a possible disease-modifying intervention as its objective is to correct...

Pediatric antibiotic and drug allergies are a major challenge for clinicians because of the difficulty in properly delineating a true immunologic reaction from an incidental allergic (non-allergic) adverse reaction. Misdiagnosing children as allergic to drugs can result in unnecessary restriction...

The feminization of labor migration is one of the most apparent Socio-demographic processes in Uzbekistan, which has to varying extent affected family structure, childcare arrangements and child health. Even though female migration is a source of household income generated from remittances, it ca...

A novel hydrogel containing povidone-iodine (a potent antiseptic) and glycerol (a moisturizer and anti-inflammatory) was designed and its effects on healing infected wounds and reducing infection-causing bacteria were investigated. The study also evaluated the hydrogel's physicochemical propertie...

This study addressed the use of activated carbon prepared from date pits as an adsorbent to remove the antibiotic amoxicillin from aqueous solutions, with the aim of evaluating its efficiency in treating water pollution with antibiotics. The results showed that the pH value had a significant impa...

Persistent organic pollutants (POPs) have been of great concern because of their toxic natures. This study investigated selected POPs in surface water, sediment and Clarias gariepinus (African Sharptooth Catfish) from four sampling locations along the Okrika axis of Bonny River, Rivers State, Nig...

Acid–base equilibria in mixed solvents are important to understand in order to explore proton-transfer reactions and solvation dynamics in industrial and analytical chemistry. Mixture systems of ethanol and glycerol give dielectric and viscosity tunability and therefore are interesting models to ...

Technogenic environmental pollution is also one of the most serious risk factors for the health of children, especially in industrially developed regions. Exposure to heavy metals and an imbalance of essential trace elements may influence the growth process as well as the formation of general som...

Ataxia-telangiectasia (A-T) is a rare and inherited disorder resulting from the biallelic mutation of the ATM gene, which results in defects in the repair of damage to DNA and genomic instability. Clinically, it is manifested by progressive cerebellar ataxia, oculomotor abnormalities, telangiecta...

Nanotechnology, particularly the development of metal and metal oxide nanoparticles, has significantly advanced medical science through improved drug delivery, diagnostic imaging, and therapeutic applications. However, conventional physical and chemical synthesis methods are often costly, energy-...

In this work, the current flow rate in a RUN3 solar cell was calculated using a [Ru(dcbpyH2)2(NCS)2] sensor where dcbpyH2-4,4′-dicarboxyl-2,2′bipyridine  when it came into contact with zinc oxide (ZnO) in a chloroform solution.A quantitative scenario was used to study the current flow rate in ord...

Klebsiella pneumoniae is an ubiquitous opportunistic pathogen, responsible for infections in hospital and non-hospital settings. It is becoming increasingly well-known for its capacity to grow resistant to so many drugs, including carbapenems. The aim of the present study was to detect MBL and ot...

Background: Vitamin D makes an important contribution to a variety of processes in human health, including immune system and bone metabolism and other metabolic processes. There are many reports that have shown an inverse association between body mass index (BMI) and blood vitamin D concentration...

The current study was designed to compare the prevalence of anticardiolipin and anti-beta2 glycoprotein I IgG and IgM antibody levels in  married women who have repeated miscarriage and had been diagnosed of recurrent pregnancy loss and normotensive women. A total of 120 women with recurrent...

The investigation combines theoretical research with practical testing to analyze the indole-based hydrazone derivatives A1 A2 and A3. The researchers achieved successful compound creation through condensation reactions which produced crystalline solids in high yield. We conducted our research by...

 CRISPR/Cas systems have attracted considerable attention because of their ability to detect and eliminate foreign nucleic acid, DNA and Genes; most amazingly, this type of process is also present within human cells here on Earth. It is like a system that has obtained immunity, such as this ...

Parkinson's disease (PD) is a complex neurodegenerative disorder that is mainly known for its movement deficits; however, its systemic effects spread to the cardiovascular and hepatic functions. This review summarises the current evidence for autonomic cardiovascular changes and liver function ch...

Cone-beam computed tomography (CBCT) has been invaluable in modern dental and maxillofacial imaging, but much remains to be desired in terms of patient radiation safety especially to sensitive organs in the head and neck area and in children. This is a thorough research utilizing an integrated Mo...

Chronic cerebral ischemia is considered to be one of the most widespread cerebrovascular disorders and is often accompanied by the progressive deterioration of cognitive abilities. Early diagnosis of cognitive impairment is vital in preventing the subsequent neurological decline and enhancing the...

Coronary heart disease (CHD) still accounted for a large proportion of all-cause mortality, oxidative stress has been proven to play an important role in the pathogenesis of CHD besides the traditional lipid abnormality. Objective: This work was oriented to the study of oxidative stress biomarker...

Cerebral palsy is one of the most common neurological disorders in childhood and is essentially characterized by motor impairment due to non-progressive damage to the developing brain. However, alongside neurological symptoms, children with cerebral palsy often have a range of systemic complicati...

Over the years, dentistry research showed that the dental implant operation is the best way to replace missing teeth, because they last a long time due to their longevity. It's functional and it looks nice, over the past forty years the state of the art in implants, in materials, the surface, in ...

Air pollution has become a major environmental and public health concern worldwide due to its significant impacts on human health and environmental sustainability. This study assessed the ambient air quality of Egbema in Ogba/Egbema/Ndoni Local Government Area of Rivers State, Nigeria, and evalua...

The task of ensuring control of the airway in obese patients is found to be more challenging because it increases the possibility of facing difficulties during intubation, thereby increasing anesthesia-related complications in obese patients. The study aims to determine how Mallampati scores and ...

Purpose: Researchers in this study set out to determine if periodontal disease patients' saliva had any histological alterations or oxidative stress. Materials and Methods: In our study, we compared two groups of periodontitis patients, one with stage I and another with stage II, using saliva and...

This work involved the synthesis of tetrazole and Hexagonal rings, saturated and unsaturated heptagonal rings azo dye  by the reaction of 4,4'-(diazene-1,2-diyl)di aniline with aldehyde group synthesis of Schiff base (S1) in ethanol through the reaction of the substituted amine in THF as a s...

Context: Both Periodontal diseases and diabetes mellitus are widespread all over the world, and if left untreated they may eventually lead to teeth loss. Iraq has little information on periodontal health and treatment requirements. According to the statistics at hand, periodontal disease is highl...

This research provides an innovative laboratory procedure for producing quality liquid soap from waste cooking oil (WCO). The two-step sequential green pretreatment improved quality: acid value was reduced from 1.50 ± 0.05 to 1.10 ± 0.03 mg KOH/g and 400 nm absorbance went from 0.50 ± 0.02 to 0.3...

Male infertility contributes substantially to the global burden of infertility and is implicated in approximately half of infertile partnerships. Contemporary evaluation has expanded beyond conventional semen analysis to include endocrine, genetic, and targeted imaging assessments, reflecting a b...

Epigenetic mechanisms, which are processes that regulate the expression of genes without changing the DNA sequence. These mechanisms are critical for adaptation of cells to various environmental cues and the ability of cells to sustain transcriptional activity. Recent research indicates that epig...

This in the article digital display devices with far term visual communication to do as a result eye surface epithelium on the floor to the surface coming morpho-functional changes analysis Clinical research during It turns out that the screen radiation under the influence eye age of the curtain ...

This study analyzes the role of immunoglobulin M (IgM) in the early stage of the immune response under conditions of food allergy. It is well known that food allergy is a hyperreactive response of the immune system to antigens and is typically mediated by mechanisms associated with immunoglobulin...

This study is aimed at assessing the levels of fertility indicators (inhibin A, activin and chorionic gonadotropin - HCG) and their dynamic changes during pregnancy in women with hyperprolactinemia, as well as determining their prognostic significance in the development of habitual miscarriage in...

This article analyzes the role, significance, and modern problems of iatrogenesis in medical practice. Iatrogenesis is a pathological condition arising as a result of medical interventions, diagnostics, or pharmacotherapy, which is one of the pressing problems of modern medicine. The study extens...

In recent years, the decline in physical activity has become a more prevalent part of the modern lifestyle, which has prompted concern on its broader physiologic effects. While the systemic impacts of hypokinesia are well-documented, its impact on the female reproductive system, especially at the...

This study examines the safe use of antibiotics in surgery, focusing on perioperative antimicrobial prophylaxis and its role in preventing postoperative infectious complications. The effectiveness of cefoperazone was evaluated in patients undergoing emergency abdominal surgery. The results showed...

This article discusses the clinical and epidemiological aspects of acute diseases of the abdominal organs among the population infected with Covid-19, information on new directions in the study of the problem. Finding a solution to this problem, identifying clinical and epidemiological markers of...

Abstract: Background: Acinetobacter baumannii has emerged as a major cause of opportunistic pathogens associated with hospital-acquired infections and multidrug resistance worldwide.  Objectives: The currwnt study aimed to detect the antimicrobial susceptibility patterns of Acinetobacter baumanni...

This study aims to evaluate the level of awareness, participation and general perception of the role of community nursing in the prevention of chronic diseases among young people. A descriptive cross-sectional study and included )100( participants from different age groups and educational levels....

The goal of this project is to create a machine learning-based system that is inclusive and can predict many chronic illnesses, including diabetes, heart disease, and chronic kidney disease. To determine which machine learning classification technique is best for disease prediction, this study us...

In the 21st century, Diabetes Mellitus Type 2 is a major health problem in the world. It occurs due to persistent hyperglycaemia and insulin resistance. If the disease is predicted in its early stages, effective prevention and management can be achieved. In this paper, some current developments i...

Nutritional status plays a crucial role in regulating central nervous system activity and adaptive behavior. Nevertheless, the physiological links between diet composition and higher nervous processes remain insufficiently integrated.  To systematize experimental evidence on how general nutr...

Type 2 diabetes mellitus and hypothyroidism are among the most common endocrine disorders and frequently coexist in the same patient, forming a clinically significant comorbidity. The combined course of these conditions is associated with pronounced disturbances in lipid metabolism, leading to a ...

Hepatocellular carcinoma (HCC) is one of the major causes of cancer death globally with most of them being diagnosed late, resistant to treatment and recurring. The phosphoinositide 3-kinase/protein kinase B (PI3K/ Akt) signaling pathway is among the essential molecular mediators of HCC progressi...

In this work, previously synthesized Schiff bases are reacted with glycolic acid using ethanol as a solvent to create heterocyclic pentacyclic rings formed from oxazolidines employing Schiff bases as nuclei. Spectroscopic measurements were used to verify the synthesized compounds' activity. Proto...

The neurovegetative (autonomic) nervous system is significant in controlling physiological reactions to cognitive and emotional stress among children. There can be significant effects of prolonged occupation of mental activity, such as chess training, on autonomic balance and adaptive capacity. H...

The aspect of children with frequent illnesses is a clinically significant subject to be further explored beyond the routine infections. Over the past few years, there has been a growing move towards background allergic diseases, especially food allergy, as a cause of morbidity recurrence. The pa...

Background: Diabetes mellitus (D M) is a chronic metabolic disorder associated with persistent hyperglycemia, insulin resistance, and systemic inflammation. One of its most serious complications is diabetic kidney disease (DKD), which evolves silently and is often underdiagnosed during its early ...

Helicobacter pylori infection remains one of the most persistent and clinically significant challenges in gastroenterology, particularly due to its strong association with chronic gastritis, peptic ulcer disease, and gastric malignancies. In recent years, the effectiveness of standard eradication...

The article examines the efficacy of centrally acting muscle relaxants (tolperisone, tizanidine, baclofen) in the complex treatment of vertebrogenic radiculopathies. Was to evaluate the impact of muscle relaxants on reducing muscle tone, alleviating pain syndrome, and improving the effectiveness ...

This study investigates the mechanisms of structural transformation of loamy (typical sierozem) and sandy saline soils from the Kegeyli and Kungrad districts of the Republic of Karakalpakstan under modification with organic structuring agents of different molecular nature—an anionic surfactant (s...

This study investigates the diagnostic and clinical significance of contrast-enhanced examination of the cerebrospinal fluid (CSF) system in children with hydrocephalus. The research is based on the analysis of 40 pediatric patients aged from 15 days to 15 years, examined using multislice compute...

This article investigated the diagnostic capabilities and clinical significance of FibroScan (transient elastography) technology in 320 patients with liver disease. During the study, the diagnostic utility of FibroScan in patients with chronic hepatitis B (n=98), chronic hepatitis C (n=87), nonal...

Lumbar osteochondrosis is one of the leading causes of disability in the modern world, occurring in 60-80% of the population over the age of 30. The rapid chronicity of the disease and the diversity of approaches to incorrect diagnosis and treatment further increase the urgency of the problem. Pu...

This study investigates the correlation between hydrochemical parameters and the body weight gain of yearling common carp (Cyprinus carpio) in ponds with different stocking densities (5,000 and 10,000 fish/ha) during the summer rearing season. The research results demonstrate that maximum weight ...

Background: Protein misfolding and aggregation is one of the fundamental disease-inducing processes in neurodegenerative diseases and systemic amyloidoses. Cellular protein quality control mechanisms maintain the protein folds in homeostasis and are unable to do so when disease develops. Objectiv...

Background; Hashimoto thyroiditis is an autoimmune illness that destroys thyroid cells through cell and antibody-mediated immunological mechanisms. In developed countries, it causes most hypothyroidism. However, iodine deficiency is the leading cause of hypothyroidism worldwide. Hashimoto thyroid...

This study evaluates the impact of seasonal fluctuations and hydrochemical water parameters on the body weight gain of common carp (Cyprinus carpio) in intensive aquaculture. The study was conducted on 1-hectare ponds that had two different stocking levels (5,000 and 7,000 fish/ha). The results s...

The compounds (W2) (6-(5-fluorothiophen-2-yl)-4-(quinolin-6-yl)pyrimidin-2(1H)-one) in this paper were previously made from α, β unsaturated carbonyl compounds known as chalcones. These compounds are typically made by reacting 6-quinolinearboxaldyde with 1-(5-fluorothiophen-2-yl)ethan-1-one. Foll...

This study aimed to evaluate serum C-reactive protein (CRP), calcium, and glucose concentrations in patients with rheumatoid arthritis (RA) in Salah al-Din Governorate and to compare these concentrations with those of a healthy control group. The study included 90 samples: 60 persons afflicted wi...

Samples were collected between October 2025 and January 2026. The study included 60 blood samples from patients diagnosed with Type 2 Diabetes Mellitus, including both males and females aged between 35 and 65 years. In addition, 30 blood samples were collected from apparently healthy individuals ...

This article investigates the impact of bio-ecological water factors on the prevalence of saprolegniosis in cyprinid fish, using fish farms in the Pastdargom district of the Samarkand region as a case study. The study determines those environmental stressors such as water acid (pH 5.46.8), relati...

This article presents the findings of a research study conducted between 2024 and 2025 on the etiology and prevention of saprolegniosis in cyprinid fish within fish farms of the Kattakurgan district, Samarkand region. The authors of the study single out the following environmental stress factors ...

The rapid increase observed in the population of Nigeria coupled with the development in the radiography profession has resulted to a strong demand for medical radiographers. This is expected to continue as the population ages. This study aimed to investigate the career plans of final year radiog...

To evaluate the method of intraoperative electroneurophysiological monitoring during surgery of a thickened terminal thread having an invasive location with nerve tissues. The study included patients from 1 year old with spina bifida, with a thickened terminal filament, with invasive - infiltrati...

This study evaluates the physicochemical characteristics of wastewater generated from a tertiary hospital in Port Harcourt, Rivers State, Nigeria. Wastewater samples were collected from six hospital wards: kitchen, laundry, theatre, paediatric ward, surgery ward, and laboratory. Standard analytic...

One of the most prevalent functional gastrointestinal disorders found in patients with type 2 diabetes mellitus (T2DM) is functional dyspepsia (FD), which has a great impact on quality of life and clinical outcomes. The aim of the study was to conduct research on the clinical characteristics, dia...

Intestinal parasitic infections constitute a major health problem that adversely affects the population, involving in excess of one billion people worldwide. Preschool children represent a particularly vulnerable population at elevated risk of infection. Maternal knowledge deficits about proper f...

Acute and chronic rhinosinusitis remain among the most common conditions in clinical practice, significantly affecting patients’ quality of life and healthcare costs. Despite the predominantly viral nature of acute rhinosinusitis, antibiotics continue to be widely prescribed, contributing to the ...

Background: Patients serve as vital quality indicators for healthcare facilities because they provide direct feedback about their medical service experiences. Healthcare providers need to understand communication patterns and provider trust and patient-centered care and service efficiency affect ...

Background: In this study, we concentrated on the peroneus longus tendon graft's effects on the ankle rather than the knee as in earlier research. Anterior cruciate ligament (ACL) injuries are often seen in sports-related injuries. Although the peroneus longus tendon graft has quickly garnered re...

Stachybotrin-type alkaloids are usually made rather than isolated. The standard route condenses a primary amine with the ortho-dialdehyde of stachybotrydial, closing the isoindolinone ring in one step. The substrate is unsymmetrical, though, and the ring can close through either aldehyde, so a si...